Effect of preparation variables on enantioselectivity of supported nickel catalysts modified with tartaric acid

摘要: Abstract Enantioselective hydrogenation of methyl acetoacetate to 3-hydroxybutyrate on various supported nickel catalysts modified with ( R,R )-tartaric acid was studied under mild reaction conditions in order examine the effects preparation variables enantioselectivity and activity resulting catalysts. The selectivity strongly dependent precipitation conditions. effect reduction depended kind support. Even Ni-alumina catalysts, when reduced relatively conditions, had high although their low. Ni-silica precipitated optimum at 400–500 °C for 1–3 h, were much more active than other similar, enantioselectivity. Various extents explained terms crystallite size distributions nickel.