Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis.
作者： Athanassios C. Tsamandas , Stavroula Salakou , Dimitrios Kardamakis , Vassiliki Zolota , Dimitrios Dougenis
DOI:
关键词:
摘要: Background: In this study the possible relation of Bax (an apoptosis promoter) to Bcl-2 (an apoptosis inhibitor) ratio with the apoptosis co-ordination enzyme, caspase-3, in the thymus of …
researchgate.net 参考文章(25)
David Hockenbery, Gabriel Nuñez, Curt Milliman, Robert D. Schreiber, Stanley J. Korsmeyer, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death Nature. ,vol. 348, pp. 334- 336 ,(1990) , 10.1038/348334A0
C. Doglioni, A. Dei Tos, L. Laurino, C. Chiarelli, M. Barbareschi, G. Viale, The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status Virchows Archiv. ,vol. 424, pp. 47- 51 ,(1994) , 10.1007/BF00197392
Emily H-Y Cheng, David G Kirsch, Rollie J Clem, Rajani Ravi, Michael B Kastan, Atul Bedi, Kazuyoshi Ueno, J Marie Hardwick, Conversion of Bcl-2 to a Bax-like Death Effector by Caspases Science. ,vol. 278, pp. 1966- 1968 ,(1997) , 10.1126/SCIENCE.278.5345.1966
Charles D. Surh, Jonathan Sprent, T-cell apoptosis detected in situ during positive and negative selection in the thymus Nature. ,vol. 372, pp. 100- 103 ,(1994) , 10.1038/372100A0
J L Tilly, K I Tilly, M L Kenton, A L Johnson, Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels. Endocrinology. ,vol. 136, pp. 232- 241 ,(1995) , 10.1210/ENDO.136.1.7828536
A. Jaretzki, R. J. Barohn, R. M. Ernstoff, H. J. Kaminski, J. C. Keesey, A. S. Penn, D. B. Sanders, Myasthenia gravis: Recommendations for clinical research standards Neurology. ,vol. 55, pp. 16- 23 ,(2000) , 10.1212/WNL.55.1.16
Randy Gascoyne, Maryla Krajewska, Ahmed Shabaik, Stanislaw Krajewski, Hong Gang Wang, Juan M. Zapata, John C. Reed, Immunohistochemical Analysis of in Vivo Patterns of Expression of CPP32 (Caspase-3), a Cell Death Protease Cancer Research. ,vol. 57, pp. 1605- 1613 ,(1997)
David G. Kirsch, Andrea Doseff, B. Nelson Chau, Dae-Sik Lim, Nadja C. de Souza-Pinto, Richard Hansford, Michael B. Kastan, Yuri A. Lazebnik, J. Marie Hardwick, Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c Journal of Biological Chemistry. ,vol. 274, pp. 21155- 21161 ,(1999) , 10.1074/JBC.274.30.21155
S Salakou, AC Tsamandas, DS Bonikos, T Papapetropoulos, D Dougenis, The potential role of bcl-2, bax, and Ki67 expression in thymus of patients with myasthenia gravis, and their correlation with clinicopathologic parameters European Journal of Cardio-Thoracic Surgery. ,vol. 20, pp. 712- 721 ,(2001) , 10.1016/S1010-7940(01)00776-X
Zoltán N. Oltval, Curt L. Milliman, Stanley J. Korsmeyer, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death Cell. ,vol. 74, pp. 609- 619 ,(1993) , 10.1016/0092-8674(93)90509-O