Induction of Asymmetry by Amino Acids
作者： Karlheinz Drauz , Axel Kleeman , J�rgen Martens
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摘要: Since the stereoisomers of molecules with one or more asymmetric centers often exhibit different biological activities (e.g. thalidomide, pheromones), stereoselective synthesis as a method preparative chemistry is rapidly attaining importance. Of numerous drugs prepared by total that contain at least center, only about 20% have so far been used in sterically pure form. Amino acids constitute greatest “chiral pool” compounds whose enantiomers can be obtained commercially large amounts; they are gradually being and frequently auxiliary agents educts syntheses.
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