Method for improving bone marrow engraftment

摘要: The present invention demonstrates that a delay in marrow infusion is associated with decrease the amount of conditioning required and improved engraftment. Surprisingly, it has been discovered for given dose TBI, transplantation up to 8 days, preferably 5 following was higher proportion animals engrafting. For conditioning, highest engrafted when delayed by 4 days. In recipients conditioned 700 cGy days did not impair establishment chimerism. treated 600 engraftment significantly if infused 1-4 compared conventional approximately 6 hours.