作者: I Azuma , M Hori , Y Yamamura , F Kanetsuna , T Taniyama
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摘要: The adjuvant activity of cell wall skeletons (mycolic acid-arabino-galactan-mucopeptide, CWS) prepared from the cells mycobacteria, nocardia and corynebacteria was examined in vivo mice guinea pigs. Mycobacterium bovis BCG (BCG-CWS), Nocardia asteroides 131 Corynebacterium diphtheriae PWC suspended Freund's incomplete (FIA) as water-in-oil emulsions showed potent on formation circulating antibody cell-mediated immunity to bovine serum albumin (BSA), sheep erythrocytes (SRBC) sulfanylazo-bovine (SA-BSA) After acetylation or acid treatment, BCG-CWS retained its activity, but destroyed completely by alkaline treatment. constituents, arabinose-mycolate arabino-galactan, no activity. It also shown that phosphate buffered saline associated with oil droplets augmented cytotoxicity which thymus-derived lymphocytes (T-cells) are effector cells.