The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.
作者： Kedar R. Mahajan , Daniel Ontaneda
DOI: 10.1007/S13311-017-0561-8
关键词:
摘要: Magnetic resonance imaging has been crucial in the development of anti-inflammatory disease-modifying treatments. The current landscape multiple sclerosis clinical trials is currently expanding to include testing not only agents, but also neuroprotective, remyelinating, neuromodulating, and restorative therapies. This especially true therapies targeting progressive forms disease where neurodegeneration a prominent feature. Imaging techniques brain spinal cord have rapidly evolved last decade permit vivo characterization tissue microstructural changes, connectivity, metabolic neuronal loss, glial activity, demyelination. Advanced magnetic hold significant promise for accelerating different treatment modalities variety pathways MS.
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