Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study.
作者： Dana Horakova , Michael G. Dwyer , Eva Havrdova , Jennifer L. Cox , Ondrej Dolezal
DOI: 10.1016/J.JNS.2008.12.005
关键词:
摘要: We assessed the relationship between gray matter (GM) and white (WM) atrophy clinical status in early relapsing-remitting multiple sclerosis (MS) patients over 5 years. A group of 181 who participated ASA (Avonex-Steroid-Azathioprine) study had complete MRI assessments 2 years was investigated. One hundred seventy (170) completed 12-month follow-up, 147 24-month, 98 36-month, 65 48-month 47 60-month. Changes GM (GMV), WM (WMV) peripheral (PGV) volumes, whole brain volume (percentage change PBVC), lateral ventricle (LVV), third width (3VW) T2-lesion (T2-LV) were measured. Patients assigned according to their one two groups: Stable group, Reached Confirmed Sustained Progression (RCSP) (24-week interval). At 0-6 months PBVC GMV, at 0-12 PBVC, GMV T2-LV, 0-24 0-36 0-48 predicted differences RCSP groups. LVV showed strongest ability differentiate presented 0 or >or=3 relapses group. Decline predictive markers disability deterioration. Correlation T2-LV with weaker decreased time. Higher number associated faster decline volume.
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