Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
作者： Zusheng Xu
DOI:
关键词:
摘要: Disclosed are a fused pyrimidine compound, an intermediate, preparation method therefor, and composition application thereof. The present invention provides compound shown in formula I, pharmaceutically acceptable salt, hydrate, solvate, optical isomer or prodrug of the compound. further applications preparing drugs for curing and/or preventing kinase-related disease. I is efficient PI3 kinase depressor, can be used to prepare cell-proliferation diseases such as cancer, infection, inflammation, autoimmune
lens.org参考文章(48)
Irina Chuckowree, Timothy Hancox, Stephen Shuttleworth, Adrian Folkes, Thieno [3,2-d] pyrimidine derivative useful as pi3k inhibitor ,(2007)
Frédéric Stauffer, Pascal Furet, Frank Stephan Kalthoff, Christian Ragot, Robert Mah, 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES ,(2010)
William Bajjalieh, Lynne Canne Bannen, Zerom Tesfai, John M. Nuss, S. David Brown, Morrison B. Mac, Patrick Kearney, Charles K. Marlowe, Wei Xu, Yong Wang, Phosphatidylinositol 3-kinase inhibitors and methods of their use ,(2006)
Daniel P. Sutherlin, Jun Li, Zachary Sweeney, Brian Safina, Purine compounds selective for PI3K P110 delta, and methods of use ,(2011)
Congxin Liang, PI3K (delta) SELECTIVE INHIBITORS ,(2010)
Changgeng Qian, Rudi Bao, Chengjung Lai, Treatment of cancers having k-ras mutations ,(2011)
Janet Gunzner, Georgette Castanedo, Tim Hancox, Daniel P. Sutherlin, Adrian Folkes, Jennafer Dotson, Vickie Tsui, Tracy Bayliss, Tim Heffron, Christian Weismann, Simon Mathieu, Alan Olivero, Richard Goldsmith, Shumei Wang, Kimberly Malesky, Sally Oxenford, Bing-Yan Zhu, Stephen Shuttleworth, Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them ,(2007)
Markus Banziger, Frank Stowasser, Sudhakar Devidasrao Garad, Salts and crystall forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile ,(2007)
Arie Zask, Kevin Joseph Curran, Jeroen Cunera Verheijen, David James Richard, Joshua Aaron Kaplan, Semiramis Ayral-Kaloustian, Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors ,(2008)