Indices of Language Outcome 11 Years After Intrathecal Chemotherapy for Acute Lymphoblastic Leukemia: A Sibling Case-Control Study

摘要: Studies are emerging that suggest major language indices do not differentiate children treated for acute lymphoblastic leukemia (ALL) with risk-adapted intrathecal chemotherapy (ITC) from control matched on age, gender, and educational level. No study to date has controlled cognitive environment, an important variable influencing achievement outcome. This case-control applies the deconfounding principle by using a sibling as investigate outcomes in male child 11 years after administration of ITC ALL at age 2 3 months. A comprehensive behavioral test battery failed siblings current performance when descriptively compared, but neurophysiological assessment revealed ITC-treated required more time elicited smaller N400 component compared his during picture-word matching. The findings absence pretreatment indices, comparison w...