PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study
作者： Amir Gholami , Sahar Nosrati , Robert N. Muller , Sophie Laurent , Cordula Grüttner
DOI: 10.1007/S10967-016-5058-0
关键词:
摘要: The purpose of this study is to evaluate the biodistribution polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration probe. Three were sacrificed at specific time intervals. data revealed high uptake by liver and spleen (60.62 12.65 %ID/g 120 min post injection for spleen, respectively). clearance other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities applying (PET-MRI) as a theranostic agent detection malignancies.
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