Sequential Control over Thiol Click Chemistry by a Reversibly Photoactivated Thiol Mechanism of Spirothiopyran

摘要: A novel photocontrolled thiol click chemistry based on spirothiopyran and maleimide is reported. Upon irradiation with λ=365 nm light, the can isomerize to open merocyanine form, a thiophenolate group, which rapidly react maleimide. The unreacted MC will readily back starting spirothiopyran, be repeatedly photoactivated as needed. Thus, this reversible confers spatiotemporal sequential control thiol–maleimide reaction using only one type of photochemical reaction. Polymer post-functionalization hydrogel building subsequent multipatterning different molecules in temporal manner indicate that Michael addition modulate specific chemical events sequence.