Structural and functional characteristic of a model for deep-seated lacunar infarct in rats
作者： Miroslaw Janowski , Elzbieta Gornicka-Pawlak , Hanna Kozlowska , Krystyna Domanska-Janik , Jerzy Gielecki
DOI: 10.1016/J.JNS.2008.06.019
关键词:
摘要: Deep-brain lacunar infarct represents a significant clinical problem as it produces severe symptoms highly resistant to rehabilitation. The limited area of necrosis may facilitate neurorepair via the action various novel neuroprotective strategies including cell-based therapies. lesion was induced by stereotactic injection ouabain into adult rat brains. Subsequent behavioral testing involved beam walking task, rotarod, visual discrimination task and apomorphine rotation. For morphological topographical analysis brain slices were stained with H-E evaluated under light microscopy. Lesion size measured in absolute terms relation whole volume. Immunohistochemical for co-localization BrdU specific cell-type markers (PSA-NCAM, NG2, beta-tubulin III, GFAP, ED1) have has been performed, determine fate newly generated cells emphasis on evidence neurogenesis. basal ganglia, forebrain nuclei, internal capsule striatum (just 1-2% total volume). Significant relatively stable deficits observed up 30 days. Furthermore, large numbers are seen be response injury proportion these being present account
elsevier.com
sci-hub.se 参考文章(62)
Ping Ye, Robert Bagnell, A. Joseph D'Ercole, Mouse NG2+ oligodendrocyte precursors express mRNA for proteolipid protein but not its DM-20 variant: a study of laser microdissection-captured NG2+ cells. The Journal of Neuroscience. ,vol. 23, pp. 4401- 4405 ,(2003) , 10.1523/JNEUROSCI.23-11-04401.2003
R IKEDA, M KUROKAWA, S CHIBA, H YOSHIKAWA, T HASHIMOTO, M TADOKORO, N SUZUKI, Transplantation of motoneurons derived from MASH1-transfected mouse ES cells reconstitutes neural networks and improves motor function in hemiplegic mice. Experimental Neurology. ,vol. 189, pp. 280- 292 ,(2004) , 10.1016/J.EXPNEUROL.2004.05.040
Shawn B. Frost, Scott Barbay, Michael L. Mumert, Ann M. Stowe, Randolph J. Nudo, An animal model of capsular infarct: Endothelin-1 injections in the rat Behavioural Brain Research. ,vol. 169, pp. 206- 211 ,(2006) , 10.1016/J.BBR.2006.01.014
K Nicolay, L.J Kappelle, P.R Bär, H.B van der Worp, J Hofmeijer, W.B Veldhuis, J Schepers, The time course of ischemic damage and cerebral perfusion in a rat model of space-occupying cerebral infarction Brain Research. ,vol. 1013, pp. 74- 82 ,(2004) , 10.1016/J.BRAINRES.2004.03.057
Shibeshih Belachew, Ramesh Chittajallu, Adan A Aguirre, Xiaoqing Yuan, Martha Kirby, Stacie Anderson, Vittorio Gallo, None, Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons. Journal of Cell Biology. ,vol. 161, pp. 169- 186 ,(2003) , 10.1083/JCB.200210110
I.M. Macrae, M. Todd, J.L. Reid, J. McCulloch, M.J. Robinson, Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat. Neuroscience Letters. ,vol. 118, pp. 269- 272 ,(1990) , 10.1016/0304-3940(90)90644-O
Pavla Jendelová, Vít Herynek, Jane DeCroos, Kateřina Glogarová, Benita Andersson, Milan Hájek, Eva Syková, Imaging the fate of implanted bone marrow stromal cells labeled with superparamagnetic nanoparticles Magnetic Resonance in Medicine. ,vol. 50, pp. 767- 776 ,(2003) , 10.1002/MRM.10585
Mary RL Dawson, Annabella Polito, Joel M Levine, Richard Reynolds, NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Molecular and Cellular Neuroscience. ,vol. 24, pp. 476- 488 ,(2003) , 10.1016/S1044-7431(03)00210-0
A. Viswanathan, A. Gschwendtner, J. -P. Guichard, F. Buffon, R. Cumurciuc, M. O'Sullivan, M. Holtmannspotter, C. Pachai, M. -G. Bousser, M. Dichgans, H. Chabriat, Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL Neurology. ,vol. 69, pp. 172- 179 ,(2007) , 10.1212/01.WNL.0000265221.05610.70
Robin J Lichtenwalner, Jack M Parent, Adult neurogenesis and the ischemic forebrain. Journal of Cerebral Blood Flow and Metabolism. ,vol. 26, pp. 1- 20 ,(2006) , 10.1038/SJ.JCBFM.9600170