The time course of ischemic damage and cerebral perfusion in a rat model of space-occupying cerebral infarction

摘要: We aimed to establish a rat model of space-occupying hemispheric infarction evaluate potential treatment strategies. For adequate timing therapy in future experiments, we studied the development tissue damage, edema formation, and perfusion over time with different MRI techniques. Permanent middle cerebral artery (MCA) occlusion was performed 32 Fisher-344 rats. Forty-six experiments including diffusion weighted (DW), T2-weighted (T2W), flow-sensitive alternating inversion recovery (FAIR) perfusion-weighted, T1-weighted (T1W) imaging before after gadolinium were at 1, 3, 8, 16, 24, 48 h ischemia. MCA consistently led complete territory. Mortality 75%. Lesion volumes as derived from apparent coefficient (ADC) T2 maps increased maximum values 400±48 mm3 24 420±54 ischemia, respectively. Midline shift peaked h. The area diffusion–perfusion deficit decreased minimum onset ischemia contralateral hemisphere dropped same point. Leakage through blood–brain barrier entire infarct occurred within 3 intraluminal rats is an for infarction. Rats may benefit intervention reducing intracranial pressure (ICP), improving blood flow, if initiated occlusion. value modalities depending on intact should be questioned.