Role of vitamin D in uterine fibroid biology.

摘要: Objective To provide a detailed summary of current scientific knowledge on uterine fibroids (leiomyomas) in vitro and in in vivo animal models, as well to postulate the potential role vitamin D3 an effective, inexpensive, safe, long-term treatment option for fibroids. Design PubMed search articles were used identify most relevant studies fibroids, effects fibroid cells tumor growth models. Setting University research laboratory. Patient(s) Not applicable. Intervention(s) None. Main Outcome Measure(s) Result(s) Despite numerous publications available information about that plays regulation is limited. Most recent D3–related published from our group. Recent have demonstrated D deficiency significant development Our reduces leiomyoma cell proliferation These results nonsurgical medical Conclusion(s) This article reviews human uncovers new possibilities understanding D–based therapeutic On basis these results, clinical trial with or hypocalcemic analog, paricalcitol, may be warranted