Chemotactic Cues for NOTCH1-Dependent Leukemia.

摘要: The NOTCH signaling pathway is a conserved cascade that regulates many aspects of development and homeostasis in multiple organ systems. Aberrant activity this linked to the initiation progression several hematological malignancies, exemplified by T-cell acute lymphoblastic leukemia (T-ALL). Interestingly, frequent non-mutational activation NOTCH1 has recently been demonstrated B-cell chronic lymphocytic (B-CLL), significantly extending pathogenic significance B-CLL. Leukemia patients often present with high-blood cell counts, diffuse disease infiltration bone marrow, secondary lymphoid organs, diffusion central nervous system (CNS). Chemokines are chemotactic cytokines regulate migration cells between tissues positioning interactions within tissue. Homeostatic chemokines their receptors have implicated regulating organ-specific infiltration, but may also directly indirectly modulate tumor growth. Recently, oncogenic shown leukemic into CNS hijacking CC-chemokine ligand 19/CC-chemokine receptor 7 chemokine axis. In addition, crucial role for homing axis CXC-chemokine 12/CXC-chemokine 4 maintenance progression. Moreover, CCL25/CCR9 gut, particularly presence phosphatase tensin homolog suppressor loss. review, we summarize latest developments regarding microenvironmental cues involved generation T-ALL compare these findings