Bacterial translocation in acute lymphocytic leukemia
作者： Yajing Song , Peter Gyarmati
DOI: 10.1371/JOURNAL.PONE.0214526
关键词:
摘要: Bloodstream infection (BSI) is the major cause of mortality in acute lymphocytic leukemia (ALL). Causative pathogens BSI originate from gut microbiota due to an increase intestinal permeability, a process known as bacterial translocation (BT). The physiological conditions controlled by large number immune cells part gut-associated lymphoid tissue (GALT).The aim current study was investigate mechanism identifying and characterizing alterations GALT leukemic mouse model. Our studies revealed severe impairment characterized loss lymphatic ALL, which eventually led BSI. We identified differentially expressed genes intraepithelium lamina propria, may contribute BT lymphocyte migration.
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