Tumor grade-related language and control network reorganization in patients with left cerebral glioma

摘要: Language processing relies on both a functionally specialized language network and domain-general cognitive control network. Yet, how the two networks reorganize after damage resulting from diffuse progressive glioma remains largely unknown. To address this issue, 130 patients with left cerebral gliomas, including 77 low-grade (LGG, WHO grade Ⅰ/II), 53 high-grade (HGG, III/IV) 38 healthy controls (HC) were adopted. The changes in resting-state functional connectivity (rsFC) of cingulo-opercular/fronto-parietal (CO-FP) examined using network-based statistics. We found that tumor negatively correlated scores integrity. Compared HCs, LGGs exhibited slight deficits, decreased increased rsFC network, nearly normal CO-FP Patients HGGs had significantly lower than those LGG more severe disruptions HCs or LGGs. Moreover, we HGGs, rsFCs positively scores. Together, our findings suggest grade-related reorganization underlie different levels impairments observed gliomas.