Aromatic diamidines as antiparasitic agents

作者: M NC Soeiro , E M De Souza , C E Stephens , D W Boykin

DOI: 10.1517/13543784.14.8.957

关键词:

摘要: Parasitic infections are widespread in developing countries and frequently associated with immunocompromised patients developed countries. Consequently, such responsible for a significant amount of human mortality, morbidity economic hardship. A growing consensus has identified the urgent need development new antiparasitic compounds, mostly due to large number drug-resistant parasites fact that currently available drugs expensive, highly toxic, require long treatment regimens exhibit significantly reduced activity towards certain parasite strains evolutive stages. In this context, aromatic diamidines been explored against range micro-organisms, authors’ present aim is review current status chemotherapy these compounds parasitic infections.

参考文章(158)
Mireille BASSELIN, Françoise LAWRENCE, Malka ROBERT-GERO, Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes. Biochemical Journal. ,vol. 315, pp. 631- 634 ,(1996) , 10.1042/BJ3150631
Roberto Docampo, Silvia N. Moreno, Current chemotherapy of human African trypanosomiasis. Parasitology Research. ,vol. 90, ,(2003) , 10.1007/S00436-002-0752-Y
F Maiso, C Fournier, D Legros, E Szumilin, M Gastellu-Etchegorry, Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda Bulletin De La Societe De Pathologie Exotique. ,vol. 92, pp. 171- 172 ,(1999)
F. Doua, J. R. Sanon Singaro, F. Boa Yapo, T. W. Miezan, T. Baltz, The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis. American Journal of Tropical Medicine and Hygiene. ,vol. 55, pp. 586- 588 ,(1996) , 10.4269/AJTMH.1996.55.586
N. Mbongo, P. M. Loiseau, F. Lawrence, C. Bories, D. G. Craciunescu, M. Robert-Gero, In vitro sensitivity of Leishmania donovani to organometallic derivatives of pentamidine Parasitology Research. ,vol. 83, pp. 515- 517 ,(1997) , 10.1007/S004360050290
Bradley J Berger, Nicola S Carter, Alan H Fairlamb, Characterisation of pentamidine-resistant Trypanosoma brucei brucei. Molecular and Biochemical Parasitology. ,vol. 69, pp. 289- 298 ,(1995) , 10.1016/0166-6851(94)00215-9
BHAGWAN DAS, RASHMI GUPTA, RENTALA MADHUBALA, Combined Action of Inhibitors of S‐Adenosylmethionine Decarboxylase with an Antimalarial Drug, Chloroquine, on Plasmodium falciparum Journal of Eukaryotic Microbiology. ,vol. 44, pp. 12- 17 ,(1997) , 10.1111/J.1550-7408.1997.TB05683.X
G Brasseur, L Favennec, D Perrine, J P Chenu, P Brasseur, Successful treatment of Acanthamoeba keratitis by hexamidine. Cornea. ,vol. 13, pp. 459- 462 ,(1994) , 10.1097/00003226-199409000-00015