TRPs in Pain Sensation.
作者： Isaac Jardín Polo , José Javier López Barba , Raquel Díez Bello , José Sánchez Collado , Carlos Cantonero Chamorro
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摘要: According to the International Association for Study of Pain (IASP) pain is characterized as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage”. The TRP super-family, compressing up 28 isoforms in mammals, mediates a myriad physiological pathophysiological processes, among them. channel might be constituted by similar different subunits, which will result formation homomeric heteromeric channels distinct properties functions. In this review we discuss about function TRPs pain, focusing on channles that participate transduction noxious sensation, especially TRPV1 TRPA1, their expression nociceptors sensitivity large number physical chemical stimuli.
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Rosa Planells-Cases, Pierluigi Valente, Antonio Ferrer-Montiel, Feng Qin, Arpad Szallasi, Complex regulation of TRPV1 and related thermo-TRPs: implications for therapeutic intervention. Advances in Experimental Medicine and Biology. ,vol. 704, pp. 491- 515 ,(2011) , 10.1007/978-94-007-0265-3_27
Minghui Li, Yong Yu, Jian Yang, Structural Biology of TRP Channels Advances in Experimental Medicine and Biology. ,vol. 704, pp. 1- 23 ,(2011) , 10.1007/978-94-007-0265-3_1
Qin Feng, Temperature Sensing by Thermal TRP Channels: Thermodynamic Basis and Molecular Insights Current Topics in Membranes. ,vol. 74, pp. 19- 50 ,(2014) , 10.1016/B978-0-12-800181-3.00002-6
P. C. Redondo, J. A. Rosado, J. A. Pariente, G. M. Salido, Collaborative effect of SERCA and PMCA in cytosolic calcium homeostasis in human platelets. Journal of Physiology and Biochemistry. ,vol. 61, pp. 507- 516 ,(2005) , 10.1007/BF03168376
Christian Harteneck, Chihab Klose, Dietmar Krautwurst, Synthetic modulators of TRP channel activity. Advances in Experimental Medicine and Biology. ,vol. 704, pp. 87- 106 ,(2011) , 10.1007/978-94-007-0265-3_4
Kinga Sałat, Barbara Filipek, Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice Journal of Zhejiang University-SCIENCE B. ,vol. 16, pp. 167- 178 ,(2015) , 10.1631/JZUS.B1400189
Irina Vetter, Richard J. Lewis, Natural Product Ligands of TRP Channels Advances in Experimental Medicine and Biology. ,vol. 704, pp. 41- 85 ,(2011) , 10.1007/978-94-007-0265-3_3
Michael J. Caterina, Tobias A. Rosen, Makoto Tominaga, Anthony J. Brake, David Julius, A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. ,vol. 398, pp. 436- 441 ,(1999) , 10.1038/18906
Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga, Tobias A. Rosen, Jon D. Levine, David Julius, The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature. ,vol. 389, pp. 816- 824 ,(1997) , 10.1038/39807
Bernd Nilius, Jean Prenen, Grzegorz Owsianik, Irritating channels: the case of TRPA1 The Journal of Physiology. ,vol. 589, pp. 1543- 1549 ,(2011) , 10.1113/JPHYSIOL.2010.200717