Epigenetics of neurological cancers.
作者： Shaun D Fouse , Joseph F Costello
DOI: 10.2217/FON.09.132
关键词:
摘要: Epigenetic mechanisms involving DNA methylation, histone modifications and noncoding RNAs regulate maintain gene-expression states. Similar to genetic mutations, alterations in epigenetic regulation can lead uncontrolled cell division, tumor initiation growth, invasiveness metastasis. Research brain cancer, particularly gliomas, has uncovered global gene-specific hypomethylation, local hypermethylation of gene promoters the de-regulation microRNA expression. Understanding dysregulation cancers provided new tools for prognostication, as well suggesting approaches therapy. There is significant interest sequencing-based technologies that map comprehensively at high resolution. These methods are being applied tumors, will better define contribution defects tumorigenesis.
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