A Clinical Trial of Pentoxifylline in Vascular Dementia

摘要: Damage to the brain from vascular disease is, after Alzheimer’s disease, second most common cause of dementia syndrome. Longitudinal studies have demonstrated that approximately 10%-20% patients with syndrome dementia; an equal percentage “mixed dementia” in which degenerative and causes both contribute cognitive impairment [23,33]. The actual incidence damage demented may be even higher. In a study serial coronal sections were stained Weigert’s stain, Brun Englund [6] found significant white matter 30 48 who met clinical neuropathological research criteria for (63%). term “multi-infarct assumes pathophysiology large majority cases is multiple, usually small, cerebral infarctions [13]. Such multiple infarcts tend affect more often than gray, leading “lacunar state” [13,21,24]. However, other mechanisms also occur, including those described originally by Binswanger [4]. Patients such diffuse are clinically heterogeneous; they develop abnormalities motor function, as gait disturbances, or indistinguishable [1,6,7]. Typical pathological findings include thinning axons, loss myelin, hyalinzation smaller vessels, varying degrees edema