摘要: A recent British-German study described ORMDL3 as a new asthma gene. Although the association with chromosome 17q12 marker is plausible from earlier linkage data, it far being clear which gene caused signal, derived large disequilibrium (LD) block. Not only Aiolos and GSDML but also distant genes that are regulated by this site may be relevant. There even unidentified RNA transcripts requiring much more detailed genetic functional analysis before finding guilty association.
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