Targeting human telomerase for cancer therapeutics.

摘要: The enzyme telomerase is involved in the replication of telomeres, specialized structures that cap and protect ends chromosomes. Its activity required for maintenance telomeres unlimited lifespan, a hallmark cancer cells. Telomerase overexpressed vast majority human cells therefore represents an attractive target therapy. Several approaches have been developed to inhibit this through targeting its RNA or catalytic components as well DNA substrate, single-stranded 3′-telomeric overhang. inhibitors are chemically diverse include modified oligonucleotides small diffusable molecules, both natural synthetic. This review presents update recent investigations pertaining these agents discusses their biological properties context initial paradigm exposure should lead progressive telomere shortening followed by delayed growth arrest response.