Accuracy validation of adjuvant! online in Taiwanese breast cancer patients - a 10-year analysis

摘要: Adjuvant! Online ( http://www.adjuvantonline.com ) is an Internet-based software program that allows clinicians to make predictions about the benefits of adjuvant therapy and 10-year survival probability for early-stage breast cancer patients. This model has been validated in Western countries such as United States, Kingdom, Canada, Germany, Holland. The aim our study was investigate performance accuracy a cohort Taiwanese Data on prognostic factors clinical outcomes 559 patients diagnosed at National Cheng Kung University Hospital Tainan between 1992 2001 were enrolled study. Comprehensive demographic, outcome data, treatment data entered into program. prediction 10 years compared with observed predicted using Online. Comparison low- high-risk patient subgroups showed significant differences tumor grading, size, lymph node status (p < 0.0001). mean death 19.44%, 15.56%. Online-predicted cancer-specific (BCSS) whole 0.001). In low-risk subgroup, did not differ significantly (3.69% 3.85%, respectively). patients, overestimated = 0.016); 21.99% 17.46%, respectively. accurately assisted decision making study, although results less accurate subgroup. Development based national database should be considered, especially Taiwan.