Hypoxia and Reactive Oxygen Species

作者: Agnes Görlach

DOI: 10.1007/978-1-4614-9167-5_4

关键词:

摘要: In recent years, superoxide and other reactive oxygen species (ROS) have been acknowledged to act not only as unwanted even toxic byproducts of aerobic metabolism but also important signaling molecules in various physiological pathophysiological conditions. This has broadened the field a substantial way given fact that is derived from molecular oxygen. this regard ROS ROS-dependent pathways appear be connected different ways involved adaptation towards low-oxygen environment.

参考文章(166)
Hogenesch Jb, Bradfield Ca, Wartman L, Moran Sm, Gu Yz, Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expression. ,vol. 7, pp. 205- ,(1998)
Agnes Görlach, Thomas Kietzmann, Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors. Methods in Enzymology. ,vol. 435, pp. 421- 446 ,(2007) , 10.1016/S0076-6879(07)35022-2
Navdeep S. Chandel, David S. McClintock, Carlos E. Feliciano, Teresa M. Wood, J. Andres Melendez, Ana M. Rodriguez, Paul T. Schumacker, Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia Journal of Biological Chemistry. ,vol. 275, pp. 25130- 25138 ,(2000) , 10.1074/JBC.M001914200
Peter J Ratcliffe, Helen J Knowles, Raju R Raval, Adrian L Harris, Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells Cancer Research. ,vol. 63, pp. 1764- 1768 ,(2003)
Agnes Görlach, Steve Bonello, The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison Biochemical Journal. ,vol. 412, pp. 571- 571 ,(2008) , 10.1042/BJ20080920
Damien Gerald, Edurne Berra, Yves M. Frapart, Denise A. Chan, Amato J. Giaccia, Daniel Mansuy, Jacques Pouysségur, Moshe Yaniv, Fatima Mechta-Grigoriou, JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress Cell. ,vol. 118, pp. 781- 794 ,(2004) , 10.1016/J.CELL.2004.08.025
L. Eric Huang, Zoltan Arany, David M. Livingston, H. Franklin Bunn, Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit Journal of Biological Chemistry. ,vol. 271, pp. 32253- 32259 ,(1996) , 10.1074/JBC.271.50.32253
Stephen W. Tuttle, Amit Maity, Patricia R. Oprysko, Alexander V. Kachur, Iraimoudi S. Ayene, John E. Biaglow, Cameron J. Koch, Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration IMPLICATIONS FOR THE MECHANISM OF HIF-1α STABILIZATION UNDER MODERATE HYPOXIA Journal of Biological Chemistry. ,vol. 282, pp. 36790- 36796 ,(2007) , 10.1074/JBC.M700327200