Positive association between congenital anomalies and risk of neuroblastoma.

摘要: Background Case reports and epidemiological studies have suggested a relationship between congenital anomalies childhood cancer, but some potential associations remain inconsistent. In this study, we investigated the association neuroblastoma. Procedure We used data of case-control study on neuroblastoma conducted from 1992 to 1994, including 538 children aged 0–19 years with newly diagnosed, histologically confirmed 504 controls identified by telephone random-digit dialing matched cases date birth. Information confounding factors was collected through maternal interviews using structured questionnaire. We estimated odds ratios (OR) 95% confidence intervals (CI), adjusted for reference age at diagnosis, mother's educational level, race, household income birth. Results An report any (OR = 2.58; CI = 1.57–4.25) observed. Neuroblastoma risk increased increasing number per child (OR = 3.90, CI = 1.27–11.9 two or more), when restricted analyses major (OR = 7.53, CI = 2.23–25.5). Genitourinary (OR = 5.84, CI = 1.67–20.4) cardiac (OR = 4.27, CI = 1.22–15.0) had an elevated, imprecise risk. Conclusions Our findings support hypothesis congenital, especially urogenital cardiac, anomalies. © 2004 Wiley-Liss, Inc.