Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
作者： Victoria Sanz-Moreno , Gilles Gadea , Jessica Ahn , Hugh Paterson , Pierfrancesco Marra
DOI: 10.1016/J.CELL.2008.09.043
关键词:
摘要: Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type movement is characterized by an elongated cellular morphology and requires extracellular proteolysis. In amoeboid movement, have a rounded morphology, are less dependent on proteases, require high Rho-kinase signaling to drive elevated levels actomyosin contractility. These interconvertible. We show that mesenchymal-type in melanoma driven activation the GTPase Rac through complex containing NEDD9, recently identified metastasis gene, DOCK3, guanine nucleotide exchange factor. signals WAVE2 direct mesenchymal suppress decreasing Conversely, activates GAP, ARH-GAP22, suppresses inactivating Rac. demonstrate tight interplay between Rho determining tumor revealing how switch
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Kazuhiko Namekata, Noriyuki Nishimura, Hideo Kimura, Presenilin-binding protein forms aggresomes in monkey kidney COS-7 cells. Journal of Neurochemistry. ,vol. 82, pp. 819- 827 ,(2002) , 10.1046/J.1471-4159.2002.01039.X
Daniel R. Croft, Michael F. Olson, Conditional regulation of a ROCK-estrogen receptor fusion protein. Methods in Enzymology. ,vol. 406, pp. 541- 553 ,(2006) , 10.1016/S0076-6879(06)06042-3
Stefan Hüttelmaier, John S. Condeelis, Erwin P. Bottinger, Jeffrey E. Segall, Yuri Oleynikov, Robert H. Singer, Weigang Wang, Victoria Centonze Frohlich, John G. White, Jiri Zavadil, Lukas Cermak, Jeffrey B. Wyckoff, Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Research. ,vol. 62, pp. 6278- 6288 ,(2002)
Erik Sahai, Christopher J. Marshall, RHO–GTPases and cancer Nature Reviews Cancer. ,vol. 2, pp. 133- 142 ,(2002) , 10.1038/NRC725
Anne J. Ridley, Rho GTPases and cell migration. Journal of Cell Science. ,vol. 114, pp. 2713- 2722 ,(2001) , 10.1242/JCS.114.15.2713
Edwin A. Clark, Todd R. Golub, Eric S. Lander, Richard O. Hynes, Genomic analysis of metastasis reveals an essential role for RhoC Nature. ,vol. 406, pp. 532- 535 ,(2000) , 10.1038/35020106
Geraldine M. O’Neill, Sarah J. Fashena, Erica A. Golemis, Integrin signalling: a new Cas(t) of characters enters the stage Trends in Cell Biology. ,vol. 10, pp. 111- 119 ,(2000) , 10.1016/S0962-8924(99)01714-6
Johannes L. Bos, Holger Rehmann, Alfred Wittinghofer, GEFs and GAPs: Critical Elements in the Control of Small G Proteins Cell. ,vol. 129, pp. 865- 877 ,(2007) , 10.1016/J.CELL.2007.05.018
Cheryl L Neudauer, James B McCarthy, Insulin-like growth factor I-stimulated melanoma cell migration requires phosphoinositide 3-kinase but not extracellular-regulated kinase activation. Experimental Cell Research. ,vol. 286, pp. 128- 137 ,(2003) , 10.1016/S0014-4827(03)00049-1
Isaiah J. Fidler, Critical determinants of cancer metastasis: rationale for therapy. Cancer Chemotherapy and Pharmacology. ,vol. 43, ,(1999) , 10.1007/S002800051091