Molecular Variances Between Right- and Left-sided Colon Cancers

摘要: During the past few years, several important clinical and molecular differences have been observed simply based on anatomic tumor location of colorectal cancer. With this review, we aimed to give an updated overview recent findings as a surrogate embryological, molecular, that direct impact our daily practice. Increasing evidence has demonstrated role for microbiota in shaping inflammatory environments promoting CRC growth spread, now know bacterial phylotypes vary depending primary location. Compelling shown sidedness both strong prognostic predictive value. In fact, right-sided colon cancers display markedly worse prognosis compared left-sided tumors; moreover, it seems RAS wild-type metastatic cancer benefits from bevacizumab-based therapy while tumors better outcomes with cetuximab-based treatment first-line setting. Since underlying reasons these are yet unknown, further investigations warranted expanding relevant field. summarize actual knowledge clinical, microbiome, between right- cancers. We also present existing data patient outcome.