Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug.
作者： Isabel Lozoya-Agullo , Marcos Planelles , Matilde Merino-Sanjuán , Marival Bermejo , Bruno Sarmento
DOI: 10.1016/J.IJPHARM.2018.12.038
关键词:
摘要: Abstract Atenolol is a drug widely used for the treatment of hypertension. However, great drawback it presents low bioavailability after oral administration. To obtain formulations that allow to improve this challenge pharmaceutical technology. The objective work was increase rate and extent intestinal absorption atenolol as model permeability drug, developing double technology strategy. an ion pair with brilliant blue designed sustained release achieved through encapsulation in polymeric nanoparticles (NPs). vitro studies showed pH-dependent from NPs, (particle size 437.30 ± 8.92) suitable profile (atenolol) counter (brilliant blue) under conditions. Moreover, vivo assays, significant (2-fold) administering ion-pair NPs by route observed. In conclusion, combination plus have proved be simple very useful approach achieve controlled charged drugs.
sci-hub.se 参考文章(49)
Alejandro Ruiz-Picazo, Isabel Lozoya-Agullo, Miguel Ortiz-Azcarate, Matilde Merino-Sanjuán, Marta González-Álvarez, Isabel González-Álvarez, Marival Bermejo, None, Comparison of segmental-dependent permeability in human and in situ perfusion model in rat European Journal of Pharmaceutical Sciences. ,vol. 107, pp. 191- 196 ,(2017) , 10.1016/J.EJPS.2017.06.033
Tauseef Ahmad, Martina Gogarty, Edwin G. Walsh, David J. Brayden, A comparison of three Peyer's patch "M-like" cell culture models: particle uptake, bacterial interaction, and epithelial histology European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 119, pp. 426- 436 ,(2017) , 10.1016/J.EJPB.2017.07.013
Isabel Lozoya-Agullo, Francisca Araújo, Isabel González-Álvarez, Matilde Merino-Sanjuán, Marta González-Álvarez, Marival Bermejo, Bruno Sarmento, PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen. European Journal of Pharmaceutical Sciences. ,vol. 115, pp. 119- 125 ,(2017) , 10.1016/J.EJPS.2017.12.009
Le Shen, Functional Morphology of the Gastrointestinal Tract Current Topics in Microbiology and Immunology. ,vol. 337, pp. 1- 35 ,(2009) , 10.1007/978-3-642-01846-6_1
Eliana B Souto, Domingos Ferreira, Susana Martins, Bruno Sarmento, Oral insulin delivery by means of solid lipid nanoparticles. International Journal of Nanomedicine. ,vol. 2, pp. 743- 749 ,(2007)
James W. McFarland, Alex Avdeef, Cynthia M. Berger, Oleg A. Raevsky, Estimating the water solubilities of crystalline compounds from their chemical structures alone. Journal of Chemical Information and Computer Sciences. ,vol. 41, pp. 1355- 1359 ,(2001) , 10.1021/CI0102822
Irina Kadiyala, Yihua Loo, Krishnendu Roy, Janet Rice, Kam W. Leong, Transport of chitosan–DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes European Journal of Pharmaceutical Sciences. ,vol. 39, pp. 103- 109 ,(2010) , 10.1016/J.EJPS.2009.11.002
Markus Flury, Hannes Flühler, Tracer Characteristics of Brilliant Blue FCF Soil Science Society of America Journal. ,vol. 59, pp. 22- 27 ,(1995) , 10.2136/SSSAJ1995.03615995005900010003X
G. Janer, E. Mas del Molino, E. Fernández-Rosas, A. Fernández, S. Vázquez-Campos, Cell uptake and oral absorption of titanium dioxide nanoparticles Toxicology Letters. ,vol. 228, pp. 103- 110 ,(2014) , 10.1016/J.TOXLET.2014.04.014
N. Samiei, V. Mangas-Sanjuan, I. González-Álvarez, M. Foroutan, A. Shafaati, A. Zarghi, M. Bermejo, Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments. European Journal of Pharmaceutical Sciences. ,vol. 49, pp. 499- 504 ,(2013) , 10.1016/J.EJPS.2013.04.025