High frequency of human papillomavirus infection in carcinoma of the urinary bladder

摘要: Background and Methods. The prevalence of type 6, 11, 16, 18, 33 human papillomavirus (HPV) was investigated with the polymerase chain reaction (PCR) on formalin-fixed, paraffin wax-embedded material, including 48 neoplastic 21 normal urinary bladder specimens. PCR-amplified DNA were analyzed by gel electrophoresis dot blot Southern hybridization. Some tissues tested further nonisotopic in situ hybridization. Results. HPV detected 39 (81%) carcinomas 7 (33%) specimens, presence high-risk (types 16,18, 33) increased significantly carcinoma cases (62%) as compared specimens (14%) (P < 0.01). Similarly, multiple infections higher (60%) than (5%) overall both distributed almost equally male female patients. There no significant correlation between positive results for histologic grades carcinoma. Conclusions. These demonstrate that sexes is another site where infection common genital tract may carry a risk malignant transformation. Cancer 1992; 70:1967-1973.