Enalapril Prevents Tubulointerstitial Lesions by Hyperoxaluria

摘要: Hyperoxaluria is a recognized cause of tubulointerstitial lesions, and this could contribute to development hypertension chronic renal failure. Enalapril has been effective against the progression lesions in various animal models. The aim present study was evaluate usefulness enalapril on damage produced by oxalates. Two-month-old male Sprague-Dawley rats were separated into 4 groups, control with tap water (G1), hyperoxaluric (G2), hyperoxaluric+enalapril (G3), (G4), for weeks. G2 G3 given 1% ethyleneglycol (ETG, precursor oxalates), G4 20 mg/L drinking water. At end study, we evaluated semiquantitative score. Urine albumin excretion, serum urine nitric oxide production, immunostaining alpha-smooth muscle actin, transforming growth factor-beta1, collagen type III measured. Rats belonging group treated (G3) showed fewer (1.3+/-0.2 versus 3+/-0.2; P<0.01), lower excretion (8+/-2 mg/d 25+/-2 mg/d; less percentage actin interstitium (2+/-0.4% 13.5+/-2.4%; factor-beta1 area (3.3+/-1% 13.3+/-2. 1%; interstitial deposition (0.7+/-0.5% 7+/-2.6%; increased NO production as well (both when compared not (G2). Considering these data, believe that enalapril, several mechanisms action, provide an important benefit prevention inflammatory response, deposition, finally, progressive fibrosis caused