Suppression of IgE responses in CD23-transgenic animals is due to expression of CD23 on nonlymphoid cells.

摘要: Serum IgE is suppressed in CD23-transgenic (Tg) mice where B cells and some T express high levels of CD23, suggesting that CD23 on may cause this suppression. However, when Tg lymphocytes were compared with controls cell proliferation synthesis assays, the two indistinguishable. Similarly, studies lymphokine production suggested function animals was normal. adoptive transfer indicated suppression seen normal used to reconstitute mice, whereas reconstitution resulted responses, critical CD23-bearing are irradiation-resistant, nonlymphoid cells. Follicular dendritic (FDC) irradiation resistant, surface deliver iccosomal Ag cells, prompting us reason FDC be a cell. High transgene expression observed germinal centers rich inhibited FDCs cultured In short, CD23-Tg appears associated population radioresistant interface center candidate for explaining CD23-mediated