Anti-hepatitis B virus activities of α-DDB-FNC, a novel nucleoside-biphenyldicarboxylate compound in cells and ducks, and its anti-immunological liver injury effect in mice.
作者： Qinghua Yang , Xuejie Zhao , Limin Zang , Xianzhen Fang , Jing Zhao
DOI: 10.1016/J.ANTIVIRAL.2012.10.003
关键词:
摘要: Abstract Infection with hepatitis B virus (HBV) continues to be a major global cause of acute and chronic liver disease high mortality. Herein, we examined both the anti-HBV hepatoprotective activity α-DDB–FNC. In human HBV-transfected cell line HepG2.2.15, α-DDB–FNC effectively suppressed secretion HBV antigens in time dose-dependent manner 25.11% inhibition on HBeAg 43.68% HBsAg at 2.5 μM day 9. Consistent antigen reduction, (2.5 μM) also reduced DNA level by 77.74% extracellularly 78.94% intracellularly duck (DHBV) infected ducks, after was given once daily for 10 days, serum DHBV levels were markedly 96.81% 97.21% 10 mg kg −1 10, respectively. Con A-induced immunological liver-injury mice, significantly inhibited elevation ALT, AST, TBiL MDA, NO levels. Furthermore, significant improvement observed treatment ducks as evaluated histopathological analysis. conclusion, our results demonstrated that possesses antiviral against effect mice.
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