Métodos analíticos para la determinación de compuestos disruptores endocrinos

摘要: espanolEsta memoria de tesis doctoral se presenta en forma compendio publicaciones cientificas segun la normativa Universidad La Rioja aprobada por Consejo Gobierno el 22 julio 2005. Siguiendo norma para presentacion Rioja, esta ha sido redactada espanol. Con fin cumplir los requerimientos solicitud del titulo "doctor con mencion internacional" incluye un resumen, articulos cientificos y las conclusiones redactados ingles. comienza describiendo tematica objetivos tesis. A continuacion encuentra una primera seccion, Introduccion, que define concepto disruptor endocrino describen detalle tecnicas extraccion empleadas sus ventajas. Despues divide capitulos dedicados a cada familias compuestos estudiados: Eteres difenilo bromados (BDEs), Alquilfenoles bisfenol (APs BPA), Compuestos perfluorados (PFCs) Retardantes llama organofosforados (OPFRs). Cada capitulo consta breve introduccion estudiados describe propiedades, fuentes emision, efectos salud, precedentes metodos analiticos su analisis, etc. pequeno resumen objetivos, resultados trabajo seguido articulo cientifico idioma original (ingles). Las encuentran recogidas son: Capitulo 2. 1. Determination of brominated diphenyl ethers (from mono- to hexa- congeners) in indoor dust by pressurized liquid extraction with cell clean-up and gas chromatography - mass spectrometry M.P. Martinez, J.D. Carrillo M.T. Tena, Analytical Bioanalytical Chemistry 397 (2010) 257-267. Focused ultrasound solid-liquid tandem determination flame retardants Martinez 404 (2012) 289-295. 3. Use microextraction packed sorbents following selective for the sewage sludge chromatography-mass Martinez-Moral Journal Chromatography 1364 (2014) 28-35. 4. determine bisphenol alkylphenols Separation Science 34 (2011) 2513-2522. 5. perfluorocompounds popcorn packaging ultra performance chromatography-tandem Talanta 101 104-109 6. perfluorinated compounds from 109 (2013) 197-202 7. Development an analysis method two novel organophosphorus sediment sludge: resorcinol bis-(diphenylphosphate) (PBDPP) bis (diphenylphosphate) (BPA-BDPP), including other organophosphate plasticizers Martinez-Moral, S. Brandsma, J. Boer P. Leonards. Para finalizar generadas durante elaboracion EnglishThis thesis, entitled "Analytical methods endocrine compounds", is presented as compilation scientific articles published during research about disruptors different kind samples. In last years concern occurrence (EDCs) environmental samples human exposure these has increased. The goal collected this memory develop simpler, faster more economical analytical EDCs such (APs), (BPA), or (OPFRs) types This begins general Introduction (in Spanish) that explains importance brief description techniques used: (SPLE), focused (FUSLE) (MEPS). Then, there are chapters each family compounds. Each chapter composed properties, uses effects environment health state-of-the-art their Spanish), followed corresponding papers, version (English). included following: Chapter 2: Brominated 3: Alkylphenols 4: Perfluorinated 5: Organophosphorus Finally, conclusions work performed