Chapter 4 Central control of the circulation by the rostral ventrolateral reticular nucleus: anatomical substrates

摘要: Publisher Summary Neurons in the rostral ventrolateral reticular nucleus (RVL), perhaps hypothetical tonic vasomotor center, generate basal levels of sympathetic tone and arterial blood pressure (AP) integrate cardiopulmonary cerebrovascular reflexes. The critical zone precisely coincides a chemosensory area rostra1 quadrant, where most reticulospinal neurons projecting to intermediolateral (IML) cosynthesize putative neurotransmitters, adrenaline, neuropeptide Y. Receptors RVL are responsive broad spectrum cardioactive pharmacologic agents is major site action imidazole, clonidine—a clinically effective antihypertensive drug. Nonetheless, still elusive identity neurotransmitter RVL-generating whether it is, fact, C1 that contribute exaggerated and, turn, circulatory changes involved initiation, expression, or maintenance neurogenic hypertension. for control derives its afferents from variety monoaminergic peptidergic cell groups.