Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases.

摘要: Skin undergoes self-renewal throughout life. Terminally differentiated keratinocytes, namely the corneocytes, are continually shed from surface of skin, whereas immature cells produce progeny that proceed through differentiation process. Notch signaling controls a number cellular processes including cell fate decision, proliferation, and survival/apoptosis. Hence, its ligands expressed in multiple tissues where they abundantly epidermis. activation results promotion growth arrest onset differentiation, therefore suggesting specific may regulate skin homeostasis by balancing these processes, i.e. functions as molecular switch transition between layers during epidermal Recent advances study have confirmed there is cross-talk pathway variety other molecules Sonic hedgehog (Shh), beta-catenin p53 family member, p63. The absence activity allows Wnt Shh to persist tissue normally repressed. In addition, counteracts action p63 maintain characteristics. However, aberrant development psoriasis cancers such squamous carcinoma, basal carcinoma malignant melanoma. Future efforts further define how proliferation lead application new therapies for various diseases.