Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice

作者: Christer Betsholtz , Marcus Fruttiger , William D. Richardson , Hans Boström , Karen Willetts

DOI: 10.1242/DEV.126.3.457

关键词:

摘要: There is a class of oligodendrocyte progenitors, called O-2A that characterized by expression platelet-derived growth factor a-receptors (PDGFR(a)). It not known whether all oligodendrocytes are derived from these PDGFRalpha-progenitors or subset(s) develops different, PDGFR alpha-negative lineage(s). We investigated the relationship between PDGF and oligodendrogenesis examining mice lack either PDGF-A PDGF-B. null had many fewer alpha-progenitors than wild-type PDGF-B mice, demonstrating proliferation cells relies heavily (though exclusively) on PDGF-AA homodimers. PDGF-A-deficient also reduced numbers dysmyelinating phenotype (tremor). Not parts central nervous system (CNS) were equally affected in knockout. For example, there profound reductions spinal cord cerebellum, but less severe both cell types medulla. This correlation suggests close link most CNS. provide evidence myelin proteolipid protein (PLP/DM-20)-positive late embryonic brainstem non-dividing cells, presumably immature oligodendrocytes, proliferating precursors.

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