Effects of continuous intracarotid infusion of dopamine during long-term hypoxia in awake goats.

作者: P. L. Janssen , M. R. Dwinell , J. Pizarro , G. E. Bisgard

DOI: 10.1007/978-1-4615-5891-0_59

关键词:

摘要: Ventilatory acclimatization to hypoxia (VAH) is the time-dependent increase in ventilation that occurs mammals (including humans) during prolonged exposure hypoxic environments. Goats acclimatize rapidly, reaching a ventilatory plateau within 4–6 hours of breathing gas (Engwall & Bisgard, 1990). Evidence strongly suggests VAH caused by carotid body (CB) sensitivity goats (Nielsen et al, 1988). However, mechanism for increased CB remains unknown.

参考文章(9)
Nancy A. Kressin, Ann M. Nielsen, Raymond Laravuso, Gerald E. Bisgard, Domperidone-induced potentiation of ventilatory responses in awake goats Respiration Physiology. ,vol. 65, pp. 169- 180 ,(1986) , 10.1016/0034-5687(86)90048-4
Mark J. Polak, Lizabeth A. Kennedy, Willa H. Drummond, Manipulation of dopamine receptors alters hypoxic pulmonary vasoconstriction in isolated perfused rat lungs Life Sciences. ,vol. 51, pp. 1317- 1323 ,(1992) , 10.1016/0024-3205(92)90630-8
S. Fidone, C. Gonzalez, K. Yoshizaki, Effects of low oxygen on the release of dopamine from the rabbit carotid bodyin vitro The Journal of Physiology. ,vol. 333, pp. 93- 110 ,(1982) , 10.1113/JPHYSIOL.1982.SP014441
P. Zapata, F. Torrealba, Blockade of dopamine-induced chemosensory inhibition by domperidone Neuroscience Letters. ,vol. 51, pp. 359- 364 ,(1984) , 10.1016/0304-3940(84)90403-8
E.B. Olson, E.H. Vidruk, D.R. McCrimmon, J.A. Dempsey, Monoamine neurotransmitter metabolism during acclimatization to hypoxia in rats Respiration Physiology. ,vol. 54, pp. 79- 96 ,(1983) , 10.1016/0034-5687(83)90115-9
Koichiro Tatsumi, Cheryl K. Pickett, John V. Weil, Possible role of dopamine in ventilatory acclimatization to high altitude Respiration Physiology. ,vol. 99, pp. 63- 73 ,(1995) , 10.1016/0034-5687(94)00084-D
C Gonzalez, L Almaraz, A Obeso, R Rigual, Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiological Reviews. ,vol. 74, pp. 829- 898 ,(1994) , 10.1152/PHYSREV.1994.74.4.829
A. M. Nielsen, G. E. Bisgard, E. H. Vidruk, Carotid chemoreceptor activity during acute and sustained hypoxia in goats Journal of Applied Physiology. ,vol. 65, pp. 1796- 1802 ,(1988) , 10.1152/JAPPL.1988.65.4.1796
M. J. Engwall, G. E. Bisgard, VENTILATORY RESPONSES TO CHEMORECEPTOR STIMULATION AFTER HYPOXIC ACCLIMATIZATION IN AWAKE GOATS Journal of Applied Physiology. ,vol. 69, pp. 1236- 1243 ,(1990) , 10.1152/JAPPL.1990.69.4.1236