作者: A.A. Vassiliou , S.A. Papadimitriou , D.N. Bikiaris , G. Mattheolabakis , K. Avgoustakis
DOI: 10.1016/J.JCONREL.2010.09.017
关键词:
摘要: Novel amphiphilic triblock copolymers of poly(propylene succinate) (PPSu) and poly(ethylene glycol) (PEG) with different hydrophobic/hydrophilic ratios were synthesized using a facile one-pot procedure. The molecular weight the was adjusted by varying PPSu while keeping that PEG constant. exhibited glass transition temperatures between -36.0 -38°C single melting points around 44°C. WAXD data indicated both blocks could crystallize. mPEG-PPSu low in vitro toxicity against HUVEC cells. used to prepare core-shell nanoparticles hydrophobic hydrophilic forming core shell, respectively. drug loading efficiency release properties investigated two model drugs: Ropinirole Tibolone. mean size drug-loaded ranged 150 300nm increased block. found be dependent upon hydrophilicity much higher for Drug characteristics also depended on hydrophilicity: released at rate than Contrary Ropinirole, profiles Tibolone an early phase burst followed slow release. By composition (mPEG/PPSu ratio) mPEG-PPSU copolymers, sizes capacities can exhibiting characteristics. Based results obtained, proposed useful various controlled delivery applications, especially those involving relatively drugs.