Facile synthesis of polyester-PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers.

作者: A.A. Vassiliou , S.A. Papadimitriou , D.N. Bikiaris , G. Mattheolabakis , K. Avgoustakis

DOI: 10.1016/J.JCONREL.2010.09.017

关键词:

摘要: Novel amphiphilic triblock copolymers of poly(propylene succinate) (PPSu) and poly(ethylene glycol) (PEG) with different hydrophobic/hydrophilic ratios were synthesized using a facile one-pot procedure. The molecular weight the was adjusted by varying PPSu while keeping that PEG constant. exhibited glass transition temperatures between -36.0 -38°C single melting points around 44°C. WAXD data indicated both blocks could crystallize. mPEG-PPSu low in vitro toxicity against HUVEC cells. used to prepare core-shell nanoparticles hydrophobic hydrophilic forming core shell, respectively. drug loading efficiency release properties investigated two model drugs: Ropinirole Tibolone. mean size drug-loaded ranged 150 300nm increased block. found be dependent upon hydrophilicity much higher for Drug characteristics also depended on hydrophilicity: released at rate than Contrary Ropinirole, profiles Tibolone an early phase burst followed slow release. By composition (mPEG/PPSu ratio) mPEG-PPSU copolymers, sizes capacities can exhibiting characteristics. Based results obtained, proposed useful various controlled delivery applications, especially those involving relatively drugs.

参考文章(32)
Glen S. Kwon, Mayumi Naito, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai, Kazunori Kataoka, Physical Entrapment of Adriamycin in AB Block Copolymer Micelles Pharmaceutical Research. ,vol. 12, pp. 192- 195 ,(1995) , 10.1023/A:1016266523505
Lwin L. Ma, Pan Jie, Subbu S. Venkatraman, Block Copolymer ‘Stealth’ Nanoparticles for Chemotherapy: Interactions with Blood Cells In Vitro Advanced Functional Materials. ,vol. 18, pp. 716- 725 ,(2008) , 10.1002/ADFM.200700634
A YANG, L YANG, W LIU, Z LI, H XU, X YANG, Tumor necrosis factor alpha blocking peptide loaded PEG-PLGA nanoparticles: preparation and in vitro evaluation. International Journal of Pharmaceutics. ,vol. 331, pp. 123- 132 ,(2007) , 10.1016/J.IJPHARM.2006.09.015
Marie Gaumet, Angelica Vargas, Robert Gurny, Florence Delie, Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 69, pp. 1- 9 ,(2008) , 10.1016/J.EJPB.2007.08.001
Yong Hu, Jingwei Xie, Yen Wah Tong, Chi-Hwa Wang, Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells Journal of Controlled Release. ,vol. 118, pp. 7- 17 ,(2007) , 10.1016/J.JCONREL.2006.11.028
Birgit Romberg, Wim E. Hennink, Gert Storm, Sheddable Coatings for Long-Circulating Nanoparticles Pharmaceutical Research. ,vol. 25, pp. 55- 71 ,(2008) , 10.1007/S11095-007-9348-7
Patrick Couvreur, Christine Vauthier, Nanotechnology: Intelligent Design to Treat Complex Disease Pharmaceutical Research. ,vol. 23, pp. 1417- 1450 ,(2006) , 10.1007/S11095-006-0284-8
Cheng Chen, Chung Him Yu, Yin Chung Cheng, Peter H.F. Yu, Man Ken Cheung, Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers. Biomaterials. ,vol. 27, pp. 4804- 4814 ,(2006) , 10.1016/J.BIOMATERIALS.2006.04.039