Genetic Polymorphisms of OPG , RANK , and ESR1 and Bone Mineral Density in Korean Postmenopausal Women
作者： J. Y. Choi , A. Shin , S. K. Park , H. W. Chung , S.I. Cho
DOI: 10.1007/S00223-004-0264-0
关键词:
摘要: To evaluate the effects of genetic polymorphisms OPG, RANK, and ESR1, which regulate osteoclastogenesis, on bone mineral density (BMD), a cross-sectional study was conducted in 650 Korean postmenopausal women. BMDs distal radius calcaneus were measured by dual energy X-ray absorptiometry (DXA). Genetic OPG 163 A > G, 1181 G C; RANK 421 C T, 575 T ESR1 1335 2142 determined matrix-assisted laser desorption/ionization—time flight (MALDI-ToF) mass spectrometry. The differences between genotypes analyzed multiple linear regression model adjusted for age body index. Women with CC genotype had higher at (7%) (10%) than those GG genotype; these statistically significant (P = 0.001 P 0.007, respectively). association also observed BMD trend 0.017). No ESR1. profound subjects TT or genotypes; women (11%) only 0.002 0.021, These results suggest that polymorphisms, especially genotypes, are related to low
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