The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

摘要: Conditions of chronic stress are associated with genetic instability in many organisms, but the roles responses mutagenesis have so far been elucidated only bacteria. Here, we present data demonstrating that environmental response (ESR) yeast functions induced by proteotoxic stress. We show drug canavanine causes stress, activates ESR, and induces at several loci an ESR-dependent manner. Canavanine-induced also involves translesion DNA polymerases Rev1 Polζ non-homologous end joining factor Ku. Furthermore, under conditions sub-lethal deletions Rev1, Polζ, Ku-encoding genes exhibit interactions ESR mutants indicative regulating these mutagenic repair processes. Analyses different stresses showed specifically modulates Together, results document first known example involvement a eukaryotic pathway important implications for mechanisms evolution, carcinogenesis, emergence drug-resistant pathogens chemotherapy-resistant tumors.