Antibodies to human tumor necrosis factor receptor-like 2
作者： Reiner L. Gentz , Jian Ni , Craig A. Rosen
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摘要: The present invention relates to novel members of the Tumor Necrosis Factor family receptors. provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. polypeptides are also provided as vectors, host cells recombinant methods for producing same. further screening identifying agonists antagonists activity. Also diagnostic detecting disease states related aberrant proliferation differentiation which express
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Bijia Deng, Naheed Banu, Beth Malloy, Philip Hass, Jian Feng Wang, Lisa Cavacini, Dan Eaton, Hava Avraham, An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis. Blood. ,vol. 92, pp. 1981- 1988 ,(1998) , 10.1182/BLOOD.V92.6.1981
Aggarwal Bb, Natarajan K, Tumor necrosis factors: developments during the last decade. European Cytokine Network. ,vol. 7, pp. 93- 124 ,(1996)
C Delgado, G E Francis, D Fisher, The uses and properties of PEG-linked proteins. Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 9, pp. 249- 304 ,(1992)
F Malik, A E Irvine, D Fisher, G E Francis, C Delgado, C Knüsli, Polyethylene glycol (PEG)-modified granulocyte-macrophage colony-stimulating factor (GM-CSF) with conserved biological activity. Experimental Hematology. ,vol. 20, pp. 1028- 1035 ,(1992)
Marvin L. Bayne, Kenneth A. Thomas, Vascular endothelial cell growth factor C subunit ,(1992)
Arlen R. Thomason, Margery A. Nicolson, Purified platelet-derived growth factor and methods for purification thereof ,(1988)
Douglas Holtzman, Sean A Mccarthy, Novel molecules of the fthma-070-related protein family and the t85-related protein family and uses thereof ,(1998)
D. Camerini, J. Borst, B. Seed, G. Walz, W. A. M. Loenen, The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. Journal of Immunology. ,vol. 147, pp. 3165- 3169 ,(1991)
Bruce A Beutler, David F Crawford, Karsten Peppel, Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells ,(1992)
I. Stamenkovic, E. A. Clark, B. Seed, A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. The EMBO Journal. ,vol. 8, pp. 1403- 1410 ,(1989) , 10.1002/J.1460-2075.1989.TB03521.X