Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells

摘要: The invention relates generally to DNA sequences encoding chimeric polypeptides comprising extracellular portions of cytokine receptor attached a sequence IgG polypeptides. generally, as well, through oligomers specifically cleavable peptide linkers heavy chain More specifically, the construction in which cDNA domain human 55 kD TNF is an oligomer thrombin-sensitive linker Fc portion and hinge region mouse IgGl chain. well uses polypeptide, including: use reagent for antagonism assay lymphotoxin from diverse species; means determining mechanism by TNF, or analogs thereof, interacts with receptor; antitumor reagent, particularly against placental tumors; and, capable controlling birth.