Glycosylated immunoglobulin and immunoadhesin comprising the same
作者： Hong-Gyu Park , Ki-Wan Yi , Kwang-Seong Kim , Hoon-Sik Cho , Yong-Hoon Chung
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摘要: The present invention relates to a glycosylated immunoglobulin or fragment thereof, in which an variant, comprising one more amino acid modifications selected from the group consisting of M160N, A195N, T243N, E265N, Y299T, F331T and Q346N, is additionally glycosylated, gene encoding same. Also, fusion protein formed as result linkage (a) variant having modified sequence forming Asn- X-Ser/Thr sequences with (b) at least biologically active portion same, recombination expression vector gene, host cell transformed transfected recombinant vector, method preparing culturing transformant transfectant isolating culture, pharmaceutical composition thus prepared.
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