swi6, a gene required for mating-type switching, prohibits meiotic recombination in the mat2-mat3 "cold spot" of fission yeast.
作者： M. J. Bonaduce , A. J. S. Klar
DOI: 10.1093/GENETICS/129.4.1033
关键词:
摘要: Mitotic interconversion of the mating-type locus (mat1) fission yeast Schizosaccharomyces pombe is initiated by a double-strand break at mat1. The mat2 and mat3 loci act as nonrandom donors genetic information for mat1 switching such that switches occur primarily (or only) to opposite allele. Location "hot spot" transposition should be contrasted with "cold meiotic recombination located within adjoining mat2-mat3 interval. That is, interchromosomal in mat2, intervening 15-kilobase region does not all. swi2 swi6 switching-deficient mutants possess normal level mat1, yet they fail switch efficiently. By testing cold spot, we found usual lack mutant but significant mutant. Therefore, gene function required keep donor inert recombination. This finding, combined additional result occurs intrachromosomally, suggests are made accessible folding them onto thus causing spot
genetics.org参考文章(28)
A.J. Klar, The developmental fate of fission yeast cells is determined by the pattern of inheritance of parental and grandparental DNA strands. The EMBO Journal. ,vol. 9, pp. 1407- 1415 ,(1990) , 10.1002/J.1460-2075.1990.TB08256.X
Yukinobu Nakaseko, Yasuhisa Adachi, Shin-ichi Funahashi, Osami Niwa, Mitsuhiro Yanagida, Chromosome walking shows a highly homologous repetitive sequence present in all the centromere regions of fission yeast. The EMBO Journal. ,vol. 5, pp. 1011- 1021 ,(1986) , 10.1002/J.1460-2075.1986.TB04316.X
K. Mather, Crossing over and Heterochromatin in the X Chromosome of Drosophila Melanogaster. Genetics. ,vol. 24, pp. 413- 435 ,(1939) , 10.1093/GENETICS/24.3.413
D.H. Beach, A.J. Klar, Rearrangements of the transposable mating-type cassettes of fission yeast. The EMBO Journal. ,vol. 3, pp. 603- 610 ,(1984) , 10.1002/J.1460-2075.1984.TB01855.X
Liang Cao, Eric Alani, Nancy Kleckner, A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae Cell. ,vol. 61, pp. 1089- 1101 ,(1990) , 10.1016/0092-8674(90)90072-M
Richard Egel, Bjarne Eie, Cell lineage asymmetry in Schizosaccharomyces pombe: unilateral transmission of a high-frequency state for mating-type switching in diploid pedigrees Current Genetics. ,vol. 12, pp. 429- 433 ,(1987) , 10.1007/BF00434820
Uhike Engelke, Lydia Grabowski, Herbert Gutz, Lutz Heim, Henning Schmidt, Molecular characterization of h − mutants of Schizosaccharomyces pombe Current Genetics. ,vol. 12, pp. 535- 542 ,(1987) , 10.1007/BF00419563
Richard Egel, Herbert Gutz, Gene activation by copy transposition in mating-type switching of a homothallic fission yeast. Current Genetics. ,vol. 3, pp. 5- 12 ,(1981) , 10.1007/BF00419574
Henning Schmidt, Petra Kapitza, Herbert Gutz, Switching genes in Schizosaccharomyces pombe: their influence on cell viability and recombination Current Genetics. ,vol. 11, pp. 303- 308 ,(1987) , 10.1007/BF00355404
Amar J.S. Klar, Lisa M. Miglio, Initiation of meiotic recombination by double-strand DNA breaks in S. pombe Cell. ,vol. 46, pp. 725- 731 ,(1986) , 10.1016/0092-8674(86)90348-X