Population clinical pharmacology of children: general principles.

摘要: Population modelling using mixed-effects models provides a means to study variability in drug responses among individuals representative of those for whom the will be used clinically. The advantages these paediatric studies are that they can analyse sparse data, sampling times not crucial and fitted around clinical procedures with missing data may still included analysis. introduction explanatory covariates explains predictable part between-individual variability. Simulations parameter estimates their investigate large numbers children – many more than is possible dealing real fraction cost, which an advantage when developing trials. Paediatric population has expanded greatly past decade now routine procedure during development investigation drugs. Children have benefitted continue benefit from this approach.