Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data

摘要: Abstract Routine clinical pharmacokinetic (PK) data collected from 59 preterm infants who received phenobarbital were analyzed to estimate population PK parameters. Birth weights ranged 600 3,620 g (mean 1,520 g), and gestational ages 24 42 weeks 31 weeks). Data using NONMEM, a computer program designed for analysis. The mean (+/- CV) clearance of was 0.0047 liter/h/kg 19%) the volume distribution (Vd) 0.96 liter/kg 16%). calculated serum half-life 141 h. Clearance not affected by age, sex, asphyxia, or duration therapy. Vd age sex but increased 13% in presence asphyxia (5-min Apgar score less than 5, p 0.05).