Paediatric pharmacokinetics: key considerations

作者: Hannah Katharine Batchelor , John Francis Marriott

DOI: 10.1111/BCP.12267

关键词:

摘要: … Pharmacokinetic clinical trials in children are complicated owing to the limitations on blood … key considerations in the design and development of paediatric pharmacokinetic clinical trials…

参考文章(86)
Thaddeus H. Grasela Jr., Steven M. Donn, Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data Developmental pharmacology and therapeutics. ,vol. 8, pp. 374- 383 ,(1985) , 10.1159/000457062
Massimo Cella, Wei Zhao, Evelyne Jacqz-Aigrain, David Burger, Meindert Danhof, Oscar Della Pasqua, Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations? British Journal of Clinical Pharmacology. ,vol. 72, pp. 454- 464 ,(2011) , 10.1111/J.1365-2125.2011.03992.X
John Lindenbaum, Jnan R. Saha, Jay F. Dobkin, Vincent P. Butler, Linda Linday, Timothy C. Wang, Digoxin Inactivation by the Gut Flora in Infancy and Childhood Pediatrics. ,vol. 79, pp. 544- 548 ,(1987)
Richard J. Grand, John B. Watkins, Frank M. Torti, Development of the Human Gastrointestinal Tract: A Review Gastroenterology. ,vol. 70, pp. 790- 810 ,(1976) , 10.1016/S0016-5085(76)80277-6
Trevor N. Johnson, M. Stuart Tanner, Christopher J. Taylor, Geoffrey T. Tucker, Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis British Journal of Clinical Pharmacology. ,vol. 51, pp. 451- 460 ,(2001) , 10.1046/J.1365-2125.2001.01370.X
S. N. De Wildt, G. L. Kearns, W. C. J. Hop, D. J. Murry, S. M. Abdel-Rahman, J. N. Van Den Anker, Pharmacokinetics and metabolism of oral midazolam in preterm infants. British Journal of Clinical Pharmacology. ,vol. 53, pp. 390- 392 ,(2002) , 10.1046/J.1365-2125.2002.01223.X
R M van Elburg, Intestinal permeability in relation to birth weight and gestational and postnatal age. Archives of Disease in Childhood-fetal and Neonatal Edition. ,vol. 88, pp. 52- 55 ,(2003) , 10.1136/FN.88.1.F52
H K Kroemer, N Holtbecker, M F Fromm, E E Ohnhaus, H Heidemann, The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism. Drug Metabolism and Disposition. ,vol. 24, pp. 1121- 1123 ,(1996)
Danny D. Shen, Kenneth E. Thummel, James D. Perkins, Christopher L. Marsh, Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher, Kent L. Kunze, Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism Journal of Pharmacology and Experimental Therapeutics. ,vol. 283, pp. 1552- 1562 ,(1997)