Prevalence of and markers for the attenuated form of congenital adrenal hyperplasia and hyperprolactinemia masquerading as polycystic ovarian disease

摘要: To determine the prevalence of attenuated form congenital adrenal hyperplasia (CAH) and hyperprolactinemia (HPPN) relative to polycystic ovarian disease (PCOD), 100 consecutive women presenting with classic clinical features PCOD were evaluated by basal hormonal profiles subsequent adrenocorticotropic hormone (ACTH) stimulation tests. The study also sought biochemical markers for CAH other than ACTH stimulation. prevalences found be as follows: PCOD, 65%; HPPN, 9%; 3%, end-organ hypersensitivity (EOH), 4%; homozygotic CAH, heterozygotic 15%. Other differential response ACTH, only observed significantly higher levels testosterone (T) 17α-hydroxyprogesterone (17-OHP). Luteinizing hormone/follicle-stimulating ratio, androstenedione, dehydroepiandrosterone sulfate all showed no significant differences between EOH. This establishes syndromes commonly mimicking PCOD. We conclude that low incidence does not justify routine testing on patients PCOD—however, our data suggest serum T 17-OHP > 50% above upper limit normal should undergo this dynamic test, especially if there are certain suggestive CAH.