Tetrazoles as carboxylic acid isosteres: chemistry and biology

摘要: Tetrazoles are often used as metabolism-resistant isosteric replacements for carboxylic acids in SAR-driven medicinal chemistry analogue syntheses. have not been found nature; with rare exceptions, these compounds do exhibit appreciable biological activity, but they at the same time resistant to degradation. This property makes it possible use tetrazoles substituents of various functional groups development biologically active substances. The tetrazole motif has drug pharmacophores a suitable replacement acid moiety and different methods synthesis using reaction conditions. review tries give vivid look on synthetic methods, catalysts or reagents tetrazoles. importance also highlighted.